The Unit of Chronotherapy is part of the "Département de Cancérologie" within the dicision "Foie et Cancers" at the hôpital Paul Brousse (Villejuif, France). Its mission is to offer anticancer treatements adapted to biological rhythms of the patient over the 24h span. To this end, the unit aims to design innovative chronotherapeutics protocols allowing for a joint increase of tratment tolerance and antitumor efficacy by adapting, not only the drug dose, but also the circadian timing of administration.

The Unit prioritize home care offering home based treatments and patient monitoring thanks to dedicated eHealth technologies. Technologies for ambulatory administration of chronotherapy protocols are optimized in cooperation with academical and industrial partners. Furthermore, the unit is involved in several training modules for both health professionals and patients, in order to secure and further disseminate ambulatory medicine (Figure 1).

The Unit of Chronotherapy was created in 1990 after recommendation of the "Comité d’Evaluation des Innovations Technologiques (CEDIT)" of the "Assistance Publique-Hôpitaux de Paris" (APHP). In 1991, the unit founded the first nurse consultation in oncology of the APHP, which was formally recommended by the "Institut National du Cancer (INCa) in 2003 (Mesure 40). It is one of the very first clinical units to offer complex home-based chemotherapy regimens. From 1990 to 2010, approximately 2800 cancer patients were taken care of. They received more than 20 000 chronotherapy cycles among which 90% were administered at home.

In 2011, the Unit started to integrate eHealth and home-based technologies. the objective is an improvement of treatment saftey and of patient monitoring at home, in particular for elderly. The European Research project InCASA which was partially coordinated by our Laboratory was recenty cited by the European commission as oen the 25 most influent project in the field of home-based medicine .


Figure 1 : From Chronotherapeutics Research to pratical applications in clinical oncology. Chronomodulated drug infusion schedules designed from translational research in our Laboratory are administered by programmablemulti-drug pumps. These equipments allow for the treatment to be given to the patient at home. The logistic organization of the Chronotherapy clinical unit relies on the complementary skills of several health professionals. It is centered on the home-care patient and involves the intervention of nurses and engineers at home






Unité INSERM U935

Campus du CNRS

Bâtiment A, 3ème étage
7 rue Guy Moquet
94801 Villejuif cedex
  • +33 (0)1 49 58 34 81